Piyush Gupta
皮尤什·古普塔
PhD
Associate Professor, Department of Biological Engineering, MIT; Core Member, Broad Institute麻省理工学院生物工程系副教授；布罗德研究所核心成员
👥Biography 个人简介
Piyush Gupta, PhD at MIT and the Broad Institute studies cancer cell state transitions, plasticity, and drug tolerance. His lab discovered drug-tolerant persister (DTP) cells that survive targeted therapy through epigenetic remodeling, identified chromatin-based mechanisms of phenotypic switching, and developed chemical screens to target plastic cancer cell states. His work bridges CSC biology and therapeutic resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Drug-Tolerant Persister Cells
Discovered a subpopulation of drug-tolerant persister (DTP) cells within cancer cell lines that survive targeted therapy via KDM5A-mediated histone H3K4 demethylation, revealing an epigenetic mechanism of non-genetic drug tolerance distinct from classical resistance.
Epigenetic Regulation of Cancer Cell State Transitions
Demonstrated that cancer cells reversibly switch between epithelial and mesenchymal states through coordinated chromatin remodeling, and identified the H3K4 demethylase KDM5A and HDAC inhibition as regulators of DTP cell formation.
Chemical Biology Screens for CSC State Targeting
Developed high-throughput phenotypic screens using induced pluripotency reprogramming and cell state reporter systems to identify small molecules that selectively eliminate drug-tolerant or stem-like cancer cell states.
Representative Works 代表性著作
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
Cell (2011)
Demonstrated that cancer cell populations maintain a phenotypic equilibrium between CSC and non-CSC states through stochastic interconversion, challenging hierarchical CSC models.
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
Cell (2010)
Identified drug-tolerant persister cells in cancer that survive therapy via KDM5A-dependent chromatin remodeling, revealing epigenetic drug tolerance as a pre-resistance mechanism.
Identifying selective inhibitors of cancer stem cells by high-throughput chemical screening
Cell (2009)
Co-authored large-scale chemical screen identifying salinomycin as a selective CSC inhibitor in breast cancer, establishing phenotypic screening for anti-CSC compounds.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
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