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Translational Medicine / 转化医学Comprehensive Genomic Profiling, FoundationOne

Philip Stephens

PhD

🏢Foundation Medicine🌐USA

Chief Scientific Officer

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Key Contributions

👥Biography 个人简介

Philip Stephens at Foundation Medicine helped develop FoundationOne CDx — one of the first FDA-approved comprehensive genomic profiling (CGP) assays for solid tumors, covering hundreds of cancer-relevant genes. His work on clinical-grade tumor genomic sequencing, interpretation of genomic alterations in clinical context, and on computing tumor mutational burden (TMB) and microsatellite instability (MSI) from sequencing data has enabled the widespread adoption of CGP in clinical oncology.

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🧪Research Fields 研究领域

comprehensive genomic profiling cancer
FoundationOne CDx cancer sequencing
tumor mutational burden MSI calculation
cancer driver alteration clinical reporting
companion diagnostic FDA approval

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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