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Translational Medicine / 转化医学Cancer DNA Damage and Replication Stress
John Petrini
PhD
🏢Memorial Sloan Kettering Cancer Center🌐USA
Member, Molecular Biology Program
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Key Papers
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Key Contributions
👥Biography 个人简介
John Petrini identified the Mre11-Rad50-Nbs1 (MRN) complex as a central mediator of the DNA damage response. His laboratory has defined how MRN initiates repair and activates ATM. He is a leading figure in double-strand break repair and cancer predisposition biology.
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🧪Research Fields 研究领域
MRN complex
double-strand break repair
NBS1
genome stability
cancer predisposition
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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