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Translational Medicine / 转化医学ADC Chemistry, Brentuximab Vedotin Pioneer

Peter Senter

PhD

🏢Seattle Genetics / Seagen🌐USA

Senior Vice President

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👥Biography 个人简介

Peter Senter at Seattle Genetics was a pioneer in antibody-drug conjugate (ADC) technology, developing the key linker-payload chemistry used in brentuximab vedotin (anti-CD30 ADC with MMAE payload) — one of the first successful ADCs. His innovations in cleavable linker design, auristatin (MMAE/MMAF) payloads, and drug-to-antibody ratio optimization created the technological foundation that subsequent ADCs have built upon.

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🧪Research Fields 研究领域

antibody-drug conjugate ADC chemistry
brentuximab vedotin MMAE linker
ADC drug-to-antibody ratio DAR
cleavable linker ADC payload
ADC technology pioneer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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