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Translational Medicine / 转化医学DNA Methylation, DNMT Inhibitors

Peter Jones

MD

🏢Van Andel Research Institute🌐USA

Chief Scientific Officer Emeritus

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Key Contributions

👥Biography 个人简介

Peter Jones is a pioneer of DNA methylation cancer epigenetics who discovered that 5-azacytidine (azacitidine) can demethylate cancer cell DNA and reactivate silenced tumor suppressor genes. His foundational laboratory research on DNMT inhibitor mechanisms directly contributed to the clinical development of azacitidine and decitabine for MDS and AML — representing one of the first validated epigenetic cancer therapies.

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🧪Research Fields 研究领域

5-azacytidine
decitabine
DNMT inhibitors
DNA demethylation
epigenetic cancer therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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