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Translational Medicine / 转化医学DNA Methylation, TE Silencing

Peter Jones

PhD, DSc

🏢Van Andel Institute🌐USA

Distinguished Professor of Medicine

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Key Contributions

👥Biography 个人简介

Peter Jones is a pioneer of DNA methylation research and epigenetic cancer therapy. His foundational work on 5-azacytidine and decitabine established DNMT inhibitors as cancer therapeutics and revealed that DNA methylation is the primary mechanism silencing transposable elements in mammalian cells. His insights into how demethylation reactivates TEs to trigger immune responses laid the groundwork for viral mimicry-based immunotherapy combinations.

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🧪Research Fields 研究领域

DNA methylation TE silencing
5-azacytidine mechanism
DNMT inhibitor
epigenetic cancer therapy
CpG island methylation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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