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Translational Medicine / 转化医学HCC Second-Line Ramucirumab, REACH-2 Trial

Peter Galle

MD

🏢University Hospital Mainz🌐Germany

Professor and Chairman, Department of Internal Medicine

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Key Contributions

👥Biography 个人简介

Peter Galle led the REACH-2 trial that established ramucirumab (anti-VEGFR2) as the first biomarker-selected therapy in advanced HCC, demonstrating benefit restricted to patients with AFP greater than or equal to 400 ng/mL. This milestone introduced prospective biomarker selection into HCC second-line treatment. He has contributed to EASL hepatocellular carcinoma guidelines and European multicenter HCC trials. His research spans the molecular pathophysiology of HCC, hepatitis-related carcinogenesis, and biomarker development for systemic therapy.

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🧪Research Fields 研究领域

ramucirumab HCC REACH-2 trial AFP biomarker
VEGFR2 inhibitor HCC biomarker-driven
HCC high AFP second-line treatment
HCC European guidelines EASL
hepatocellular carcinoma pathophysiology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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