Peter Carmeliet
彼得·卡梅利特
MD, PhD
Full Professor and VIB Group Leader; Head, Laboratory of Angiogenesis & Vascular Metabolism正教授及VIB课题组长；血管生成与血管代谢实验室主任
👥Biography 个人简介
Peter Carmeliet is among the world's foremost authorities on VEGF biology and vascular development. His laboratory discovered key mechanisms governing endothelial cell tip/stalk cell selection during vessel sprouting and pioneered endothelial cell metabolism as a therapeutic target, expanding the framework for anti-angiogenic drug design.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Endothelial Tip/Stalk Cell Biology
Discovered Notch-DLL4 signaling controls tip versus stalk endothelial cell fate during vessel sprouting, revealing a new mechanism for regulating angiogenesis independent of VEGF abundance.
Endothelial Cell Metabolism
Pioneered the concept of endothelial metabolic reprogramming as a driver of angiogenesis, identifying PFKFB3 as a critical glycolytic target and opening a new therapeutic avenue beyond VEGF blockade.
Representative Works 代表性著作
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Nature (1996)
Demonstrated haploinsufficiency of VEGF causes embryonic lethality, establishing the exquisite dose-sensitivity of vascular development to VEGF levels.
Targeting endothelial cell metabolism by inhibiting PFKFB3 reduces pathological angiogenesis
Cell Metabolism (2013)
Showed that blocking glycolysis in endothelial cells via PFKFB3 inhibition suppresses tumor angiogenesis, introducing metabolic targeting as an anti-angiogenic strategy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Naiyer A. Rizvi
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