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Translational Medicine / 转化医学AML Novel Targets, FLT3 Inhibitors

Alexander Perl

MD

🏢University of Pennsylvania Abramson Cancer Center🌐USA

Professor of Medicine, Hematology-Oncology

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Key Contributions

👥Biography 个人简介

Alexander Perl leads FLT3 inhibitor development at Penn and was principal investigator of the ADMIRAL trial establishing gilteritinib for relapsed/refractory FLT3-mutated AML. He has characterized resistance mechanisms and optimal sequencing of FLT3 inhibitors. His work has defined the FLT3 inhibitor class in AML.

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🧪Research Fields 研究领域

FLT3 inhibitors
gilteritinib
quizartinib
ADMIRAL trial
FLT3 resistance

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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