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Translational Medicine / 转化医学Bispecific Antibody Engineering

Paul Parren

PhD

🏢Leiden University Medical Center🌐Netherlands

Professor of Antibody Technology

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👥Biography 个人简介

Paul Parren at Leiden University is an internationally recognized expert in antibody engineering including bispecific antibody formats and Fc engineering. His laboratory has contributed to the development of multiple bispecific antibody platforms including DUOBODY and other IgG-based bispecific formats. He has worked at the interface of structural biology and therapeutic antibody engineering to optimize tumor cell killing mechanisms. His expertise spans blinatumomab-related BiTE technology to next-generation CD3-engaging bispecifics across hematologic and solid tumors.

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🧪Research Fields 研究领域

bispecific antibody engineering
antibody formats
Fc engineering
bispecific T-cell engagers
antibody drug discovery

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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