Paul Brown
MD
Professor
👥Biography 个人简介
Treatment of brain metastases has evolved significantly — stereotactic radiosurgery (SRS) has largely replaced whole-brain radiation therapy (WBRT) for limited brain metastases due to superior neurocognitive preservation. Checkpoint immunotherapy has demonstrated intracranial activity in melanoma and NSCLC brain metastases, and targeted therapies (tucatinib, osimertinib) have demonstrated CNS activity in HER2+ and EGFR-mutant brain metastases — transforming the treatment of this common complication of cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-03-01 | All information from publicly available academic sources
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