Paul Bhatt

Paul Bhatt investigates the molecular mechanisms of neoantigen processing and presentation on MHC class I molecules in cancer cells. His research has revealed how tumors down-regulate antigen presentation machinery to escape T cell recognition. He has developed methods to predict neoantigen presentability from genomic data and validated predictions using mass spectrometry-based immunopeptidomics. His work informs better neoantigen prioritization strategies for cancer vaccines and TCR therapy.