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Translational Medicine / 转化医学CAR-T Therapy, B7-H3 Targeting

Paul Bhatt

MD

🏢Seattle Children's Research Institute🌐USA

Associate Professor of Oncology

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Key Contributions

👥Biography 个人简介

Paul Bhatt focuses on B7-H3-targeted CAR-T cell therapies for pediatric solid tumors and diffuse intrinsic pontine glioma. B7-H3 is broadly expressed across many solid tumor types with limited normal tissue expression, making it an attractive CAR-T target. His research has advanced novel CAR constructs with improved antitumor activity and safety profiles. He has conducted first-in-human trials of B7-H3 CAR-T in children with refractory solid tumors.

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🧪Research Fields 研究领域

B7-H3 CAR-T
pediatric solid tumors
diffuse intrinsic pontine glioma
immune checkpoint
cell therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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