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Translational Medicine / 转化医学Epigenetic Drug Development, HDAC BET

Paul Bhatt

PhD

🏢Pfizer Oncology🌐USA

Senior Director of Epigenetics

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Key Contributions

👥Biography 个人简介

Paul Bhatt leads epigenetic drug development programs in oncology with expertise in HDAC inhibitors and BET bromodomain inhibitors. His industry research characterized the activity of vorinostat and romidepsin in hematologic malignancies and contributed to their FDA approval. He has developed next-generation HDAC inhibitors with improved selectivity profiles and studied their combination with immunotherapy. His work on epigenetic priming to enhance chemotherapy and immunotherapy response spans multiple tumor types.

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🧪Research Fields 研究领域

HDAC inhibitor development
vorinostat romidepsin
BET inhibitor cancer
epigenetic drug combinations
DNMT inhibitor cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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