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Translational Medicine / 转化医学Stress Granules, Cancer Survival

Paul Anderson

MD, PhD

🏢Brigham and Women's Hospital / Harvard Medical School🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

Paul Anderson has been a foundational figure in stress granule biology, elucidating how these phase-separated RNA-protein assemblies form under cellular stress and contribute to cancer cell survival. His work revealed that stress granules sequester pro-apoptotic signaling components, enabling tumor cells to withstand chemotherapy and hypoxia. These insights have motivated therapeutic strategies to disrupt stress granule formation and sensitize cancer cells to treatment.

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🧪Research Fields 研究领域

stress granules
RNA granules cancer
translational control
TIA-1/TIAR
cancer cell stress response

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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