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Translational Medicine / 转化医学Neoantigen Vaccine Clinical Trials, Melanoma

Patrick Ott

MD, PhD

🏢Dana-Farber Cancer Institute🌐USA

Associate Professor of Medicine

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👥Biography 个人简介

Patrick Ott led the landmark NeoVax personalized neoantigen vaccine clinical trials at Dana-Farber Cancer Institute, demonstrating safety and immunogenicity in melanoma patients. His Phase 1 trial results showed that neoantigen vaccines combined with anti-PD-1 therapy produced durable responses. He has continued to advance neoantigen vaccine development into glioblastoma and other tumor types. His clinical research has established the proof-of-concept for personalized cancer vaccines in humans.

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🧪Research Fields 研究领域

personalized neoantigen vaccine
melanoma immunotherapy
NeoVax clinical trials
checkpoint inhibitor combination
clinical oncology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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