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Translational Medicine / 转化医学Phase I Immunotherapy, Cancer Vaccines

Patricia Ott

MD

🏢Dana-Farber Cancer Institute🌐USA

Associate Professor

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👥Biography 个人简介

Patricia Ott at Dana-Farber has led pivotal early phase trials of personalized neoantigen vaccines in cancer. Her landmark 2017 Nature paper reporting a small trial of individualized mutanome vaccines in melanoma — showing feasibility, immunogenicity, and early signals of clinical activity — helped launch the personalized cancer vaccine field. She has continued to develop mRNA-based neoantigen vaccine approaches in combination with pembrolizumab.

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🧪Research Fields 研究领域

neoantigen vaccine clinical trials
mRNA cancer vaccine phase I
personalized cancer vaccine
checkpoint pembrolizumab combinations
phase I immunotherapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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