Patricia LoRusso
帕特里夏·洛鲁索
DO
Professor of Medicine; Leader, Developmental Therapeutics医学教授；发展性治疗学项目负责人
👥Biography 个人简介
Patricia LoRusso is a veteran leader in early-phase oncology drug development with over 30 years of experience. She has pioneered clinical development of bispecific antibodies, novel immune modulators, and targeted agents, leading hundreds of first-in-human trials and shaping US early-phase trial infrastructure.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Bispecific Antibody Development
Led early-phase trials of multiple bispecific antibodies targeting tumor-immune synapses, defining safety, activity, and optimal dosing for T-cell engager platforms.
ADC Clinical Pharmacology
Contributed to clinical development of landmark ADCs including sacituzumab govitecan and others, establishing dosing frameworks and managing novel toxicity profiles.
Early-Phase Trial Infrastructure
Built and led world-class phase I programs at Karmanos Cancer Institute and Yale, training a generation of early-phase trial investigators and developing national safety monitoring standards.
Representative Works 代表性著作
First-in-Human Phase I Study of AMG 701 (Anti-BCMA Bispecific T-Cell Engager) in Relapsed/Refractory Multiple Myeloma
Journal of Clinical Oncology (2021)
Defined safety and efficacy profile of AMG 701 bispecific T-cell engager, demonstrating deep responses in heavily pre-treated myeloma.
Phase I Study of Sacituzumab Govitecan in Metastatic Solid Tumors
Clinical Cancer Research (2017)
Early-phase characterization of TROP2-directed ADC safety and efficacy, enabling subsequent pivotal trials in breast and urothelial cancers.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Alison Schram
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