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Translational Medicine / 转化医学T-Cell Lymphoma, Pralatrexate

Owen O'Connor

MD, PhD

🏢Columbia University Irving Medical Center🌐USA

Professor of Medicine and Director, Center for Lymphoid Malignancies

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👥Biography 个人简介

Owen O'Connor led the development and clinical investigation of pralatrexate, the first drug approved specifically for relapsed/refractory PTCL based on the PROPEL trial. His research has been foundational in establishing regulatory pathways for novel agents in T-cell lymphomas and demonstrating proof-of-concept for antifolate therapy in this disease. He is an international advocate for T-cell lymphoma clinical trial development.

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🧪Research Fields 研究领域

pralatrexate
antifolate therapy lymphoma
PTCL-NOS therapy
PROPEL trial
T-cell lymphoma novel agents

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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