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Translational Medicine / 转化医学mRNA/Peptide Cancer Vaccines

Patrick Ott

MD, PhD

🏢Dana-Farber Cancer Institute🌐USA

Associate Professor of Medicine

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👥Biography 个人简介

Patrick Ott is a leader in personalized cancer vaccine development at Dana-Farber Cancer Institute, having conducted the seminal clinical trial demonstrating that individualized neoantigen peptide vaccines can generate robust T cell responses and durable clinical benefit in melanoma patients. His work on the NeoVax personalized vaccine platform established the proof of concept that computationally predicted neoantigens can effectively prime anti-tumor immunity in humans. He continues to advance neoantigen vaccine approaches in combination with checkpoint inhibitors across multiple tumor types.

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🧪Research Fields 研究领域

Personalized neoantigen peptide vaccines
Tumor mutanome analysis
Vaccine-induced T cell responses
Melanoma immunotherapy
Cancer vaccine clinical trials

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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