Omid C. Farokhzad
奥米德·法罗哈扎德
MD, MSc
Professor; Founder, BIND Biosciences & Selecta Biosciences教授;BIND Biosciences & Selecta Biosciences创始人
👥Biography 个人简介
Omid Farokhzad is a Professor at Harvard Medical School and Brigham and Women's Hospital. He is one of the world's leading translational nanomedicine researchers and entrepreneurs, known for developing targeted polymeric nanoparticle platforms that have advanced to human clinical trials. Working closely with Robert Langer, he developed PLGA-PEG nanoparticles functionalized with cancer-targeting aptamers — a platform that became the basis for BIND-014, the first targeted nanoparticle to enter Phase II clinical trials for cancer treatment. He co-founded multiple companies including BIND Biosciences (NASDAQ) and Selecta Biosciences. His laboratory focuses on engineering nanoparticles that can navigate biological barriers, reach tumor targets, and deliver drugs with unprecedented precision, overcoming the limitations of standard chemotherapy.
Omid Farokhzad 是哈佛医学院和布莱根妇女医院的教授。他是世界领先的转化纳米医学研究者和企业家,以开发进入人类临床试验的靶向聚合物纳米颗粒平台而闻名。 与Robert Langer密切合作,他开发了用癌症靶向适配体功能化的PLGA-PEG纳米颗粒——这一平台成为BIND-014的基础,即第一个进入II期癌症治疗临床试验的靶向纳米颗粒。他共同创立了多家公司,包括BIND Biosciences(纳斯达克上市)和Selecta Biosciences。
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Targeted Polymeric Nanoparticles for Cancer
Developed aptamer-functionalized PLGA-PEG nanoparticles that selectively target prostate cancer cells via PSMA receptor. This platform became BIND-014, demonstrating tumor-specific drug delivery in clinical trials.
BIND-014 Clinical Translation
Successfully translated targeted nanoparticle technology from bench to first-in-class Phase II clinical trial (BIND-014 for prostate and lung cancer), establishing proof-of-concept for targeted nanomedicine in humans.
Tolerogenic Nanoparticles (Selecta)
Developed ImmTOR — synthetic vaccine particles that generate antigen-specific immune tolerance, enabling re-dosing of gene therapies and biologics without neutralizing antibody formation.
RNA Delivery Nanoparticles
Engineered lipid-polymer hybrid nanoparticles for mRNA and siRNA delivery, bridging polymer nanoparticle engineering with RNA therapeutics.
Representative Works 代表性著作
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
PNAS (2006)
Demonstrated in vivo tumor targeting and therapeutic efficacy of aptamer-functionalized nanoparticles in mouse cancer models.
Combination delivery of TGF-β inhibitor and IL-2 by nanoscale liposomal polymeric gels enhances tumour immunosuppression reversal
Nature Materials (2012)
Advanced combination immunotherapy delivery using nanoparticle platforms.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-04-05 | All information from publicly available academic sources
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