Omar Abdel-Wahab
奥马尔·阿卜杜勒-瓦哈卜
MD
Associate Member and Physician, Human Oncology & Pathogenesis Program; Attending Physician, Leukemia Service人类肿瘤学与发病机制项目副研究员及医师；白血病服务主治医师
👥Biography 个人简介
Defined the landscape of spliceosome mutations in myeloid cancers, demonstrating that SF3B1, SRSF2, and U2AF1 mutations are among the most frequent driver alterations in MDS and AML. Leader in therapeutic targeting of aberrant splicing.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Spliceosome Mutations in MDS/AML
Identified recurrent hotspot mutations in splicing factors SF3B1, SRSF2, U2AF1, and ZRSR2 as major drivers of myelodysplastic syndromes, transforming understanding of RNA biology in cancer.
Splicing Factor Therapeutic Targeting
Demonstrated that cancer cells with spliceosome mutations show synthetic lethality with splicing inhibitors, paving the way for clinical trials of splicing modulator drugs.
Representative Works 代表性著作
Recurrent mutations affecting RNA splicing in myelodysplastic syndromes
Nature Genetics (2011)
Identified SRSF2, U2AF35, ZRSR2 mutations as common drivers of MDS via aberrant RNA splicing.
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia
New England Journal of Medicine (2011)
Whole-exome sequencing revealing SF3B1 as a major CLL driver affecting RNA splicing.
Altered RNA splicing by mutant IDH2 and SRSF2 in leukemia
Cell (2015)
Mechanistic link between metabolic mutations and spliceosome dysfunction in AML.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
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