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Translational Medicine / 转化医学Myeloma MRD, Ultra-Deep Sequencing, Early Disease

Ola Landgren

MD, PhD

🏢University of Miami Sylvester Comprehensive Cancer Center🌐USA

Professor of Medicine; Director, Myeloma Program

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👥Biography 个人简介

Ola Landgren is an internationally recognized leader in myeloma minimal residual disease (MRD) and the biology of precursor plasma cell diseases. He pioneered the application of next-generation sequencing-based MRD testing (clonoSEQ) as a sensitive and specific endpoint in myeloma clinical trials, contributing to its FDA clearance. His epidemiologic work established that virtually all myeloma is preceded by MGUS or SMM, creating a framework for cancer prevention. He led clinical trials of first-line quadruplet therapy with MRD-driven endpoints and has authored influential consensus recommendations for MRD standardization.

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🧪Research Fields 研究领域

myeloma MRD next-generation sequencing clonoSEQ
MGUS to SMM to myeloma progression biology
precursor disease biology myeloma
MRD negativity as endpoint myeloma
smoldering myeloma biologic risk

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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