Roel Nusse
PhD
Professor of Developmental Biology
👥Biography 个人简介
Roel Nusse co-discovered the Wnt gene family as proto-oncogenes activated by mouse mammary tumor virus integration, founding the entire Wnt signaling field and its central role in cancer stem cell biology. His biochemical characterization of Wnt ligand lipid modification, Frizzled receptor binding, and LRP5/6 co-receptor activation defined the molecular events initiating canonical Wnt signaling that maintains cancer stem cell self-renewal. His demonstration that purified Wnt3a sustains intestinal stem cell growth in culture provided the foundation for cancer organoid technology and Wnt-targeted therapy development.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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