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Translational Medicine / 转化医学Bone Metastasis, Bone Marrow Niche

Nora Heisterkamp

PhD

🏢Children's Hospital Los Angeles, University of Southern California🌐USA

Professor of Pediatrics, Pathology and Laboratory Medicine

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👥Biography 个人简介

Nora Heisterkamp is a molecular biologist specializing in hematopoietic signaling and bone marrow niche biology with translational relevance to leukemia and cancer bone marrow involvement. Her research has characterized CXCR4-CXCL12 axis signaling in cancer cell homing to bone marrow, providing therapeutic targets to disrupt protective interactions between tumor cells and the bone marrow niche. She investigates how bone marrow stromal cells confer chemotherapy resistance to leukemia and cancer cells. Her work has implications for mobilization strategies and disrupting bone marrow sanctuary sites.

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🧪Research Fields 研究领域

bone marrow niche cancer
hematopoietic stem cell niche
ALL bone marrow
tumor cell bone marrow homing
CXCR4 bone marrow trafficking

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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