Noa Biran
诺阿·比兰
MD
Associate Professor of Medicine; Director, Myeloma Program医学副教授；骨髓瘤项目主任
👥Biography 个人简介
Noa Biran, MD is Associate Professor of Medicine and Director of the Myeloma Program at Hackensack University Medical Center's John Theurer Cancer Center. A leading CAR-T cell therapy specialist in myeloma, she participated in the KarMMa trials of idecabtagene vicleucel and CARTITUDE studies of ciltacabtagene autoleucel, contributing to both approvals. She focuses on optimizing patient selection and managing toxicities of cellular therapies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Idecabtagene Vicleucel (ide-cel) Clinical Development
Served as site investigator for KarMMa and KarMMa-3 trials, contributing to FDA approval of ide-cel (bb2121) as the first BCMA-targeted CAR-T therapy for myeloma. Provided expertise on cytokine release syndrome management and bridging therapy optimization.
Real-World CAR-T Implementation in Myeloma
Led real-world studies of CAR-T outcomes at a high-volume academic center, defining predictors of response, durability, and toxicity in clinical practice outside trial settings, informing patient selection criteria and post-CAR-T monitoring protocols.
Representative Works 代表性著作
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma (KarMMa)
New England Journal of Medicine (2021)
Phase II KarMMa trial demonstrating 73% ORR with ide-cel in heavily pretreated myeloma including 33% complete responses, supporting FDA approval of the first BCMA CAR-T therapy.
Real-World Outcomes of BCMA-Targeted CAR-T Cell Therapy in Multiple Myeloma
Blood Advances (2023)
Multicenter real-world analysis characterizing outcomes of ide-cel and cilta-cel in routine clinical practice, identifying factors predicting durable responses and early progression post-CAR-T.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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