Nitzan Rosenfeld
尼赞·罗森菲尔德
PhD
Senior Group Leader; Professor of Cancer Genomics高级课题组组长；癌症基因组学教授
👥Biography 个人简介
Leading authority on cfDNA biology and liquid biopsy technology. Developed Plasma-Seq for copy number profiling from plasma and pioneered cfDNA fragmentation analysis as a cancer diagnostic signal. His work bridges fundamental cfDNA biology with clinical cancer detection applications.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
cfDNA Fragmentation Analysis
Discovered that cfDNA fragmentation patterns reflect chromatin accessibility of tissue of origin, enabling non-invasive transcription factor activity inference from blood samples.
Plasma-Seq Technology
Developed low-pass whole genome sequencing of plasma DNA to detect copy number alterations in cancer, advancing affordable and accessible liquid biopsy approaches.
Representative Works 代表性著作
Genome-wide cell-free DNA fragmentation in patients with cancer
Nature (2019)
Landmark study showing cfDNA fragmentation profiles reflect open chromatin and transcription factor activity, enabling cancer detection and tissue-of-origin classification.
Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin
Cell (2016)
Demonstrated nucleosome positioning shapes cfDNA fragmentation, linking fragment size to chromatin structure of source tissue.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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