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Translational Medicine / 转化医学Liquid Biopsy, ctDNA Detection Methods

Nitzan Rosenfeld

PhD

🏢Cancer Research UK Cambridge Institute, University of Cambridge🌐UK

Professor of Cancer Research

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👥Biography 个人简介

Nitzan Rosenfeld is a leader in circulating tumor DNA (ctDNA) technology who developed CAPP-Seq (Cancer Personalized Profiling by deep Sequencing) for ultrasensitive ctDNA detection. His research has demonstrated ctDNA-based minimal residual disease detection capabilities far beyond conventional imaging in lymphoma and solid tumors. He has pioneered fragmentomics analysis of cell-free DNA to infer cell-of-origin and tissue type in multi-cancer early detection contexts. His methodological advances have pushed ctDNA sensitivity limits and expanded liquid biopsy applications across the cancer care continuum.

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🧪Research Fields 研究领域

ctDNA detection
CAPP-Seq
minimal residual disease
cancer fragmentomics
liquid biopsy methods

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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