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Translational Medicine / 转化医学Chronic Lymphocytic Leukemia, TP53/del17p

Nitin Jain

MD

🏢University of Texas MD Anderson Cancer Center🌐USA

Associate Professor, Department of Leukemia

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👥Biography 个人简介

Nitin Jain is a clinical investigator specializing in high-risk CLL, particularly TP53-mutated and del17p disease for which standard chemoimmunotherapy is largely ineffective. His research has characterized outcomes with BTK inhibitors and venetoclax combinations in this genomically high-risk subgroup. He leads early-phase clinical trials of novel agents and CAR-T cell therapies for CLL and explores strategies to achieve deep molecular remissions. His work on MRD monitoring and genomic evolution of CLL under targeted therapy pressure informs optimal treatment sequencing.

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🧪Research Fields 研究领域

TP53 del17p CLL
high-risk CLL management
ibrutinib del17p
CAR-T CLL
CLL minimal residual disease

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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