Laura Niedernhofer
MD, PhD
Professor of Biochemistry, Molecular Biology and Biophysics and Director of Institute on the Biology of Aging and Metabolism
👥Biography 个人简介
Laura Niedernhofer co-discovered fisetin as a potent natural senolytic and has advanced it through preclinical and clinical evaluation for aging and cancer prevention. Her ERCC1 DNA repair-deficient mouse models demonstrate accelerated senescent cell accumulation and cancer susceptibility that is reversed by senolytic treatment. She leads the AFFIRM-LITE clinical trial evaluating fisetin for reduction of senescent cell burden and cancer-related biomarkers in older adults.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 Laura Niedernhofer 的研究动态
Follow Laura Niedernhofer's research updates
留下邮箱，当我们发布与 Laura Niedernhofer（University of Minnesota）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment