Nicola Valeri

Nicola Valeri, MD, PhD is Professor of Molecular Pathology at The Institute of Cancer Research (ICR) and Consultant Medical Oncologist at The Royal Marsden NHS Foundation Trust in London. He is a leading European authority on mismatch repair deficiency (dMMR) and microsatellite instability-high (MSI-H) as biomarkers for immunotherapy, particularly in gastrointestinal cancers. His laboratory has made seminal contributions to the biology of dMMR in colorectal and gastric cancer, including characterizing mechanisms of secondary MMR loss and POLE/POLD1 mutations as alternative hypermutation pathways. Valeri's translational work has contributed to standardizing MSI-H/dMMR testing across IHC and molecular methods in European clinical practice and has informed the integration of universal dMMR screening in colorectal cancer pathology workflows. He has also been a leader in liquid biopsy and ctDNA research, developing approaches for monitoring minimal residual disease and treatment response in gastrointestinal cancers.