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Translational Medicine / 转化医学Breast Cancer, ESR1 Resistance ctDNA
Nicholas Turner
MD, PhD
🏢Institute of Cancer Research / Royal Marsden🌐UK
Professor of Molecular Oncology
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Key Papers
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Key Contributions
👥Biography 个人简介
Nicholas Turner defined the role of ESR1 mutations detected in circulating tumor DNA as drivers of endocrine resistance and co-led PADA-1 showing ctDNA-guided therapy switching improves outcomes. His translational work underpins the move to biomarker-directed sequencing of endocrine therapies.
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🧪Research Fields 研究领域
ESR1 mutations
ctDNA monitoring
PADA-1 trial
PALOMA-3 biomarkers
endocrine resistance
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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