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Translational Medicine / 转化医学CDK4/6 Inhibitor Mechanisms, ESR1

Nicholas Turner

PhD, MBBS

🏢The Institute of Cancer Research / Royal Marsden Hospital🌐UK

Professor of Molecular Oncology

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Key Contributions

👥Biography 个人简介

Nicholas Turner at the Institute of Cancer Research and Royal Marsden is a leading translational researcher in HR-positive breast cancer. He has characterized mechanisms of CDK4/6 inhibitor resistance and pioneered ctDNA-based monitoring of ESR1 mutations during endocrine therapy. His PLAYTIME, CAPItello, and other trial contributions have defined optimal sequencing of CDK4/6 inhibitors and next-line endocrine strategies.

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🧪Research Fields 研究领域

palbociclib ribociclib abemaciclib mechanisms
CDK4/6 resistance
ESR1 ctDNA
endocrine therapy sequencing
breast cancer translational

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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