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Translational Medicine / 转化医学BRAF Mutations Biliary Cancer, RAF/MEK Targeting

Nicholas Bhatt

MD, PhD

🏢University of Texas MD Anderson Cancer Center🌐USA

Associate Professor of GI Medical Oncology

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👥Biography 个人简介

Nicholas Bhatt investigates BRAF-mutated biliary tract cancers and RAF/MEK inhibitor strategies for this molecular subset. His research has characterized the prevalence and functional significance of BRAF V600E and non-V600E BRAF mutations in intrahepatic cholangiocarcinoma and gallbladder cancer. He has evaluated BRAF/MEK combination inhibitor strategies in BRAF V600E-mutated biliary tract cancers translating results from melanoma and colorectal cancer into biliary oncology. His translational work investigates combination strategies pairing BRAF/MEK inhibitors with EGFR blockade or immunotherapy to overcome adaptive resistance in BRAF-mutated biliary tract cancers.

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🧪Research Fields 研究领域

BRAF V600E cholangiocarcinoma
RAF/MEK inhibitors BTC
BRAF non-V600E
intrahepatic cholangiocarcinoma
targeted therapy BTC

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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