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Translational Medicine / 转化医学Bone Tumor, Chordoma

Nadia Sorel

PhD

🏢Institut Gustave Roussy🌐France

Research Scientist, Chordoma Program

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Key Contributions

👥Biography 个人简介

Nadia Sorel investigates the molecular biology of chordoma — a rare malignant bone tumor arising from notochordal remnants — and the activity of targeted agents including imatinib (targeting PDGFR-beta) and denosumab in chordoma. Her translational work has characterized brachyury overexpression as the key oncogenic driver in chordoma and identified rational targets for therapeutic intervention. She collaborates with the international Chordoma Foundation research network.

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🧪Research Fields 研究领域

chordoma molecular biology
imatinib chordoma PDGFR
brachyury transcription factor
chordoma targeted therapy
skull base chordoma

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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