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Translational Medicine / 转化医学Molecular Clock, Cancer Timing

Moritz Gerstung

PhD

🏢German Cancer Research Center (DKFZ) / EMBL🌐Germany

Group Leader, Computational Cancer Biology

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Key Contributions

👥Biography 个人简介

Moritz Gerstung led the timing analysis in the Pan-Cancer Analysis of Whole Genomes (PCAWG) project, establishing molecular clocks for reconstructing the evolutionary history of cancer genomes. His work revealed that many driver mutations and chromosomal gains occur years to decades before cancer diagnosis, redefining the timeline of cancer evolution. He has developed Bayesian methods for ordering mutational events and estimating their timing relative to cancer diagnosis.

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🧪Research Fields 研究领域

molecular clock cancer
mutation timing
cancer evolution reconstruction
whole genome doubling timing
PCAWG timing

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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