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Translational Medicine / 转化医学Waldenstrom's Macroglobulinemia, BTK Resistance

Monique Minnema

MD, PhD

🏢University Medical Center Utrecht🌐Netherlands

Hematologist and Clinical Researcher

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Key Contributions

👥Biography 个人简介

Monique Minnema investigates the mechanisms and clinical management of BTK inhibitor resistance in Waldenstrom's macroglobulinemia, including resistance mutations at the BTK C481 site and downstream escape pathways. Her clinical research addresses optimal salvage regimens for patients who fail BTK inhibitor therapy and the development of next-generation BTK inhibitors for WM. She participates in the European WM Research Group.

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🧪Research Fields 研究领域

BTK resistance WM
ibrutinib discontinuation WM
WM salvage therapy
Bruton's tyrosine kinase resistance
WM relapsed refractory

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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