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Translational Medicine / 转化医学Hippo/YAP Pathway, Drug Resistance

Monica Bhatt

PhD

🏢Institute of Cancer Research🌐UK

Associate Professor of Pharmacology

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Key Contributions

👥Biography 个人简介

Monica Bhatt investigates how YAP/TAZ activation mediates resistance to targeted cancer therapies. Her research has shown that YAP is a major mechanism through which cancer cells survive EGFR, KRAS, and BRAF inhibitor therapy. She has characterized upstream signals that reactivate YAP following oncogene inhibition and developed rational combination strategies to block YAP-driven resistance. Her work has significantly advanced understanding of bypass resistance mechanisms and combination treatment approaches.

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🧪Research Fields 研究领域

YAP-mediated drug resistance
targeted therapy resistance
EGFR resistance YAP
bypass signaling
combination therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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