Miriam Koopman
米里亚姆·库普曼
MD, PhD
Professor of Medical Oncology, Principal Investigator Colorectal Cancer肿瘤内科学教授、结直肠癌首席研究员
👥Biography 个人简介
Miriam Koopman is the Netherlands' foremost colorectal cancer clinical researcher, leading CAIRO and CAIRO5 trials on sequencing strategies in metastatic CRC. She champions treatment optimization for elderly CRC patients and chairs the Dutch Colorectal Cancer Group, integrating molecular profiling into national care pathways.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CAIRO5 CRC Conversion Therapy
Led CAIRO5 trial optimizing conversion therapy regimens for initially unresectable CRC liver metastases, identifying optimal doublet versus triplet regimens based on RAS/BRAF molecular status.
Elderly CRC Patient Care
Established geriatric assessment-integrated treatment approaches for elderly metastatic CRC patients, reducing chemotherapy overtreatment while preserving efficacy in fit older adults.
Representative Works 代表性著作
FOLFOX plus bevacizumab versus FOLFOXIRI plus bevacizumab for resectable and potentially resectable metastatic colorectal cancer (CAIRO5)
Lancet Oncology (2023)
Defined molecular subgroup-specific optimal conversion regimens for liver-limited metastatic CRC based on RAS/BRAF status.
Systemic treatment for colorectal cancer in elderly patients: a Dutch population-based registry study
European Journal of Cancer (2021)
Population-based study informing treatment optimization for elderly CRC patients in the Netherlands.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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