Milind Javle
米林德·贾夫勒
MD
Professor, Department of Gastrointestinal Medical Oncology胃肠肿瘤内科学教授
👥Biography 个人简介
Milind Javle, MD is a Professor of Gastrointestinal Medical Oncology at MD Anderson Cancer Center and a world-leading authority on biliary tract cancers. He has spearheaded pivotal trials of FGFR2-targeted therapies (pemigatinib, infigratinib) and IDH1 inhibitor ivosidenib in cholangiocarcinoma, fundamentally expanding precision oncology for this underserved malignancy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FGFR2-Targeted Therapy in Cholangiocarcinoma
Conducted seminal trials establishing pemigatinib and infigratinib as effective FGFR2 fusion-targeted agents in intrahepatic cholangiocarcinoma, leading to FDA approvals and setting a new standard for biomarker-driven treatment.
IDH1 Inhibition in Biliary Tract Cancer
Led investigations into ivosidenib for IDH1-mutated cholangiocarcinoma, contributing to approval of the first IDH1-directed therapy in biliary tract cancer and advancing precision oncology in this disease.
Representative Works 代表性著作
Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study
The Lancet Oncology (2020)
FIGHT-202 trial demonstrating clinically meaningful responses to pemigatinib in FGFR2 fusion-positive cholangiocarcinoma, leading to FDA approval.
Infigratinib in patients with advanced cholangiocarcinoma with FGFR2 gene fusions/translocations
Journal of Clinical Oncology (2021)
Phase II trial establishing infigratinib efficacy in FGFR2-altered cholangiocarcinoma with durable objective responses.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
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Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
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