Miguel-Angel Perales
米格尔-安赫尔·佩拉莱斯
MD
Chief, Adult Bone Marrow Transplant Service (Interim); Professor of Medicine成人骨髓移植科代主任，医学教授
👥Biography 个人简介
Miguel-Angel Perales is a leading authority in allogeneic hematopoietic cell transplantation and GvHD prevention at MSKCC. His research has refined T-cell depletion strategies, post-transplant cyclophosphamide platforms, and integration of CAR-T therapy with transplant, improving outcomes across diverse hematologic malignancies.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
T-Cell Depletion and GvHD Prevention
Advanced CD34-selected graft engineering at MSKCC, achieving very low rates of severe GvHD while maintaining potent graft-versus-leukemia effects in high-risk disease.
Post-Transplant Cyclophosphamide
Led trials applying post-transplant cyclophosphamide to matched and mismatched unrelated donor settings, expanding access to transplantation.
CAR-T and Transplant Integration
Pioneered clinical trials examining CAR-T cell therapy as a bridge to or consolidation after allogeneic transplant in relapsed/refractory lymphoma and leukemia.
Representative Works 代表性著作
Ex vivo T-cell depletion in allogeneic hematopoietic stem cell transplantation: past, present and future
Bone Marrow Transplantation (2021)
Comprehensive review of T-cell depletion strategies defining the current landscape and future directions.
High-dose post-transplantation cyclophosphamide with tacrolimus and mycophenolate mofetil for HLA-mismatched unrelated donor HCT
Biology of Blood and Marrow Transplantation (2020)
Demonstrated feasibility and efficacy of PTCy-based GvHD prophylaxis in unrelated donor transplants.
CAR T-cell therapy in large B-cell lymphoma: who should go to transplant?
Hematology (ASH Education Program) (2022)
Framed the clinical decision between CAR-T and autologous transplant in relapsed lymphoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Effie Petersdorf
Fred Hutchinson Cancer Center
Sergio Giralt
Memorial Sloan Kettering Cancer Center
Joseph H. Antin
Dana-Farber Cancer Institute / Brigham and Women's Hospital
Stephanie J. Lee
Fred Hutchinson Cancer Center
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