Effie Petersdorf
埃菲·彼得斯多夫
MD
Professor, Division of Medical Oncology; Member, Clinical Research Division医学肿瘤学教授，临床研究部成员
👥Biography 个人简介
Effie Petersdorf is a world-leading authority on HLA biology and unrelated donor hematopoietic stem cell transplantation. Her decades of research at Fred Hutch have defined HLA matching criteria that now guide global donor selection, substantially improving transplant outcomes for patients lacking matched siblings.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HLA Matching Science
Established landmark evidence on the impact of HLA-A, -B, -C, -DRB1, and -DQB1 mismatches on survival, forming the basis of current international donor selection guidelines.
Unrelated Donor Transplantation
Pioneered large-scale studies through the NMDP/Be The Match registry demonstrating how high-resolution HLA typing improves transplant survival in unrelated donor settings.
Permissive HLA Mismatches
Identified specific HLA mismatches that are immunologically permissive, enabling broader donor pools without compromising patient outcomes.
Representative Works 代表性著作
HLA-C and HLA-DQ antigens and the outcome of unrelated donor hematopoietic cell transplantation
Blood (2001)
Foundational study establishing HLA-C and HLA-DQ as critical matching loci for unrelated donor transplant outcomes.
Association of HLA mismatches with transplant-related mortality after unrelated-donor hematopoietic cell transplantation
NEJM (2004)
Seminal NEJM paper defining the survival impact of each HLA locus mismatch in unrelated donor transplantation.
Differential effects of HLA class I and class II incompatibility on rejection, graft-versus-host disease and survival after HLA-mismatched unrelated donor transplantation
Journal of Clinical Oncology (2008)
Differentiated immunologic consequences of class I vs. class II mismatches, refining donor selection strategy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Joseph H. Antin
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Stephanie J. Lee
Fred Hutchinson Cancer Center
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