Michelle Monje
米歇尔·蒙赫
MD, PhD
Professor of Neurology and Neurological Sciences神经病学与神经科学教授
👥Biography 个人简介
Michelle Monje is a world-leading neuro-oncologist and neuroscientist at Stanford renowned for elucidating the biology of DIPG/DMG, discovering the H3K27M oncohistone's role in gliomagenesis, and pioneering ONC201 clinical translation for H3K27M-mutant diffuse midline gliomas.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DIPG/DMG Biology
Characterized H3K27M histone mutation as the defining oncogenic driver in diffuse midline glioma and established patient-derived DIPG models enabling preclinical drug discovery.
ONC201 Clinical Translation
Led preclinical and translational studies supporting ONC201 (dordaviprone) trials in H3K27M-mutant DMG, contributing to its FDA approval for this pediatric brain tumor.
Neural-Tumor Interactions
Discovered that neurons drive glioma proliferation via electrochemical synapses, opening a new therapeutic paradigm targeting the tumor microenvironment.
Representative Works 代表性著作
Synaptic proximity enables NMDAR signalling to promote brain metastasis
Nature (2023)
Demonstrated neuron-to-tumor synaptic signaling drives glioma growth, identifying NMDA receptor blockade as a therapeutic strategy.
ONC201 induces cell death in H3K27M-mutant diffuse midline glioma
Cancer Cell (2022)
Preclinical validation of ONC201 efficacy in DMG models, supporting clinical trials leading to regulatory approval.
Diffuse intrinsic pontine glioma and non-brainstem H3K27M-mutant diffuse midline glioma
Nature Reviews Clinical Oncology (2020)
Comprehensive review defining DMG classification, molecular landscape, and emerging therapeutic approaches.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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