Michele De Palma
米凯莱·德帕尔马
PhD
Associate Professor, Swiss Institute for Experimental Cancer Research (ISREC)瑞士实验癌症研究所副教授
👥Biography 个人简介
Michele De Palma investigates how tumor endothelial cells and myeloid cells cooperate to sustain tumor angiogenesis and resist anti-VEGF therapy. His discovery of angiocrine functions of endothelial cells—where they instruct tumor cell behavior beyond blood supply—has opened new therapeutic concepts for targeting tumor vasculature.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Angiocrine Functions of Tumor Endothelium
Demonstrated that tumor endothelial cells secrete angiocrine factors that directly promote tumor cell survival and stemness independent of oxygen delivery, redefining endothelium as an active tumor-supporting compartment.
Myeloid Cell-Mediated Anti-VEGF Resistance
Showed that myeloid cells (TIE2-expressing monocytes) are recruited to tumors following VEGF blockade and restore angiogenesis via alternative pathways, identifying a key escape mechanism for combination targeting.
Representative Works 代表性著作
Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications
Nature Medicine (2005)
Identified a distinct TIE2-expressing monocyte population that home to tumors and potently promote angiogenesis, revealing a myeloid bypass mechanism for anti-VEGF resistance.
Tumor-vessel crosstalk: endothelial angiocrine signals as cancer hallmarks
Cancer Cell (2017)
Comprehensive analysis of how endothelial angiocrine factors shape tumor progression and therapy resistance beyond their classical role in vascular supply.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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