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Translational Medicine / 转化医学CD19 CAR-T, Cell Engineering

Michel Sadelain

MD, PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Director, Center for Cell Engineering

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Key Contributions

👥Biography 个人简介

Michel Sadelain at Memorial Sloan Kettering co-developed the modern CAR architecture and conducted foundational research on CD19-targeted T cells. His laboratory has engineered key improvements in CAR costimulatory domains and vector design that influence all current CAR-T products. He continues to develop next-generation constructs targeting solid tumor antigens with enhanced persistence and safety.

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🧪Research Fields 研究领域

CD19 CAR-T design
CAR construct optimization
T cell persistence
solid tumor CAR
lentiviral vector engineering

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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