Michael Yaffe
迈克尔·亚菲
MD, PhD
David H. Koch Professor of Science; Member, Koch Institute for Integrative Cancer Research大卫·科赫科学教授；科赫综合癌症研究所成员
👥Biography 个人简介
Expert in cell signaling networks, DNA damage response, and synergistic drug combination design. Has developed computational and experimental systems biology approaches to understand how cancer cells integrate multiple oncogenic signals and respond to DNA-damaging agents, identifying non-intuitive synergistic drug combinations.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Signaling Networks and Drug Synergy
Applied systems biology and phosphoproteomics to map how cancer cells integrate multiple oncogenic signals, discovering non-obvious synergistic drug combinations targeting DNA damage response and cell cycle checkpoints that overcome drug resistance.
Representative Works 代表性著作
Systems-level network model of sequential organ failure post trauma predicts acute lung injury from early arterial lactate
PLOS Computational Biology (2012)
Demonstrated systems biology network modeling for predicting biological outcomes, with applications to cancer drug resistance and combination therapy optimization.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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Drew M. Pardoll
Johns Hopkins University
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Naiyer A. Rizvi
Columbia University Irving Medical Center
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