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Translational Medicine / 转化医学Precision Medicine

Michael R. Stratton

M.D., Ph.D., FRS

🏢Wellcome Sanger Institute🌐United Kingdom

Director

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Michael Stratton is a world leader in cancer genomics who directs the Wellcome Sanger Institute. His work on BRCA genes, cancer mutational signatures, and systematic cancer genome sequencing has transformed understanding of cancer biology. The catalogue of somatic mutations in cancer (COSMIC) developed under his leadership is an essential resource for cancer research.

Michael Stratton是癌症基因组学的世界领导者,领导威康桑格研究所。他在BRCA基因、癌症突变特征和系统性癌症基因组测序方面的工作改变了对癌症生物学的理解。在他的领导下开发的癌症体细胞突变目录(COSMIC)是癌症研究的重要资源。

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🧪Research Fields 研究领域

Cancer Genomics癌症基因组学
Mutational Signatures突变特征
BRCA GenesBRCA基因

🎓Key Contributions 主要贡献

BRCA2 Discovery

Co-discovered BRCA2 gene and its role in hereditary breast cancer.

Mutational Signatures

Characterized mutational processes operative in cancer.

COSMIC Database

Established catalogue of somatic mutations in cancer.

Representative Works 代表性著作

[1]

Signatures of mutational processes in human cancer

Nature (2013)

Comprehensive analysis of mutational signatures.

🏆Awards & Recognition 奖项与荣誉

🏆Fellow of the Royal Society
🏆Breakthrough Prize in Life Sciences (2018)

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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