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Translational Medicine / 转化医学ovarian cancer molecular biology

Michael J. Birrer

迈克尔·比勒

MD, PhD

🏢University of Alabama at Birmingham O'Neal Cancer Center(阿拉巴马大学伯明翰分校奥尼尔癌症中心)🌐USA

Director主任

64
h-index
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Key Papers
2
Awards
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Key Contributions

👥Biography 个人简介

Michael Birrer is a leading gynecologic oncology researcher who has contributed seminal molecular biology discoveries and clinical trial leadership in ovarian cancer. As a long-standing GOG investigator, he led or co-led multiple transformative trials including GOG 252 (carboplatin/paclitaxel dosing) and has contributed to molecular characterization of HRD subsets benefiting from platinum. Birrer directed the MGH ovarian cancer program for many years before leading UAB Cancer Center. His laboratory work on the molecular heterogeneity of ovarian cancer histotypes has informed subtype-specific treatment development and biomarker identification.

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🧪Research Fields 研究领域

ovarian cancer molecular biology卵巢癌分子生物学
GOG clinical trialsGOG临床试验
homologous recombination deficiency同源重组缺陷
bevacizumab ovarian cancer贝伐珠单抗卵巢癌
platinum resistance铂类耐药

🎓Key Contributions 主要贡献

Ovarian Cancer Molecular Characterization

Led molecular profiling studies characterizing distinct ovarian cancer histotypes at the genomic level, identifying subtype-specific vulnerabilities and supporting histotype-specific clinical trial design.

GOG Platinum-Based Regimen Trials

Led pivotal GOG trials evaluating carboplatin-paclitaxel dose scheduling and bevacizumab combinations, contributing to evidence base for first-line ovarian cancer standard of care.

Representative Works 代表性著作

[1]

Randomized Phase III Trial of Intraperitoneal and Intravenous Chemotherapy in Ovarian Cancer

New England Journal of Medicine (2006)

GOG 172 establishing IP chemotherapy superiority in optimally debulked ovarian cancer.

[2]

Molecular Subtypes of High Grade Serous Ovarian Cancer

Journal of Clinical Oncology (2013)

Molecular characterization of HGSOC subtypes with distinct biology.

🏆Awards & Recognition 奖项与荣誉

🏆SGO Distinguished Scientist Award
🏆NCI Cancer Center Support Grant Principal Investigator Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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