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Translational Medicine / 转化医学Tumor Heterogeneity, Single-Cell Evolution

Michael Bhatt

PhD

🏢Broad Institute of MIT and Harvard🌐USA

Associate Professor of Cancer Biology

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👥Biography 个人简介

Michael Bhatt uses single-cell genomics to dissect tumor heterogeneity and clonal evolution at unprecedented resolution. His research has developed methods for tracking copy number evolution and clonal dynamics within tumors using single-cell DNA sequencing. He has characterized cell-state plasticity in cancer as a mechanism of adaptive resistance distinct from genetic heterogeneity. His work using lineage tracing approaches has revealed developmental hierarchies within tumors and the origins of cancer cell diversity.

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🧪Research Fields 研究领域

single-cell sequencing tumor
copy number evolution
cancer subclone dynamics
lineage tracing
cell-state plasticity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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