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Translational Medicine / 转化医学WNT Signaling, Gastrointestinal Cancer

Michael Bhatt

MD, PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Professor of Gastroenterology and Oncology

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👥Biography 个人简介

Michael Bhatt focuses on the clinical translation of WNT pathway targeting in gastrointestinal cancers. His research examines APC mutation heterogeneity and its impact on WNT pathway activity across colorectal cancer subtypes. He leads clinical trials evaluating porcupine inhibitors and LGR5-targeted therapies in metastatic colorectal cancer. His work integrates patient-derived organoid models with clinical response prediction.

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🧪Research Fields 研究领域

colorectal cancer
WNT pathway
APC mutations
tumor organoids
clinical trials

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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